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Research Technician

Requisition ID:  24705

Newcastle, GB

Contract Type:  Fixed Term
Working Pattern:  Full Time
Posted Date:  16-Nov-2022


We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.


What’s in it for you? Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.


Newcastle is an inclusive global University community where everyone is treated with dignity and respect.  As a University of Sanctuary, we aim to provide a welcoming place of safety for all, offering opportunities to people fleeing violence and persecution.


Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains colleagues from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.


Salary: £23,144 to £24,285 with progression to £31,411 per annum


Closing Date: 01 December 2022


The Role

We are looking for an enthusiastic Technician to join a Rosetrees Trust funded project within the Newcastle Fibrosis Research Group under the direct supervision of Prof Fiona Oakley with significant oversight from Prof Derek Mann.

You will be responsible for day-to-day management of experimental work to develop a novel human liver slice ex vivo culture model to study liver cancer and test potential cancer limiting therapies. The project will involve tissue cultures (ex vivo slice cultures and primary cells) as well as using histological, biochemical and molecular approaches.


You will be responsible for collection, processing, analysis, presentation (writing, graph production, image production and oral presentations at national/international conferences) and storage of experimental data in accurate, secure, detailed and up- to-date records of all work carried out to GLP standard.


Reporting to the Technical Manager, the role will require specific technical and practical skills and a well-developed working knowledge of technical practices and procedures, acquired by considerable experience on the job and/or vocational training. The post will work as part of a professional community to provide a technical support service to staff and students by following established working patterns, but there will be a need to resolve most problems without access to more senior colleagues. The role may involve developing skills in a particular specialist area or planning and supervising the work of others. 


This post is tenable for 1 year with the potential for further extension. 


For informal enquiries please contact Professor Fiona Oakley  


Key Accountabilities

•    Develop and use a novel ex vivo human liver cancer slice culture model. This will involve the generation and culture of precision cut tissue slices and primary cells as well as a wide range of molecular and cell biology techniques, including: immunohistochemistry, immunofluorescence, FACS, ELISA, RNA extraction, RT-PCR etc, as required
•    To facilitate the fibrosis group in other aspects of its operation including contribution to laboratory meetings, contribution to web-based activities and contribution to its public engagement activities
•    To facilitate general management and running of the laboratory including routine laboratory cleaning, maintenance, equipment upkeep and ordering of laboratory materials
•    Analyse data statistically and have a major input into both the experimental design and methodology
•    Manage his/her time effectively and work independently on a day-to-day basis, but also work closely with Project supervisors and other members of the research team
•    Attend research seminars and other departmental meetings as required. Contribute to the presentation of results to the group and to the research community in general
•    Ensure that all work done in the laboratory complies with the applicable regulations concerning biohazards and radiation
•    Arrange equipment maintenance and repair, as necessary
•    Contribute to the preparation reports and scientific publications, as requested by project coordinators
•    Comply with University policies, including financial regulations, equal opportunities policy, health and safety policy, promoting race equality policy, information systems security policy, data security and intellectual property rights
•    Carry out any other duties, which may arise commensurate with the grade of the post, as requested by the project coordinators
•    Complete a range of maintenance activities and repairs
•    Liaise with suppliers and manufacturers to resolve problems and investigate replacement options
•    By developing local procedures, establish and maintain a safe/compliant working environment
•    Assist with the completion and updating of a wide range of safety paperwork
•    Complete accident reporting 
•    Maintain broad and up to date health and safety knowledge providing support/advice to others
•    Schedule, prioritize and monitor work and performance in line with demands and deadlines
•    Hold delegated responsibility from the academic/technical lead for the planning, operation, and supervision of a variety of laboratory spaces
•    Organize and facilitate progress and management meetings 
•    Oversee local record keeping, inventory and asset management
•    Monitor resource usage and stores operations 
•    Source and negotiate with suppliers for a range of items including specialist parts/equipment 
•    Create, update and implement procedures to deliver an aligned, efficient and effective service
•    Design, develop and deliver inductions, demonstrations and training covering a broad range of activities (not limited to techniques and equipment)
•    Develop a broad knowledge and skills base, sharing with others 
•    Mentor junior staff
•    Any other duties within the scope and general nature of the grade which may be required

The Person (Essential)


Knowledge, Skills and Experience 

•     An in depth understanding of cell and molecular biology with a particular focus on liver disease and /or liver cancer
•     Demonstrable previous skills in cell culture techniques 
•     Demonstrable previous skills in histology, immunohistochemistry and/or immunofluorescence staining
•     RNA extraction from cells and tissue, PCR, real-time PCR (Sybr Green and molecular probe based)
•     ELISA
•     Experience/Awareness of laboratory Health and Safety issues/procedures and experience of safe waste management 
•     Good teamwork, excellent interpersonal, oral and written communication skills
•     Excellent record-keeping, time management and organisational skills
•     Ability to prioritise workload and plan effectively
•     Ability to adapt to changes in teaching/research priorities
•     Good computer skills, with the ability to graph and statistically analyse data
•     Willingness to work outside normal hours when necessary
•    Demonstrable work experience in a relevant technical laboratory role
•    Demonstrates technical and problem solving capability

•    Contribute to design and specification of teaching/research activities 
•     Demonstrable previous skills in complex 3D cell models or tissue slices 
•     Ability to modify and apply new methods to advance the project 
•     Skills working with clinical specimens and samples 
•     Specific lab experience specific to role 


Attributes and Behaviour

•    Excellent oral and written communication skills 
•    Good interpersonal skills to interface with staff
•    Attention to detail to ensure accuracy and precision
•    Work in a collaborative and flexible way
•    To exhibit University and Faculty values and principles
•    Works collaboratively with others, plays a positive role in teams and establishes and grows relationships across the organisation where different skills, expertise and opinions are valued
•    Respects the expertise and contribution of others even if own opinion is different
•    Shares relevant and useful information with others
•    Keeps other team members up to date with progress
•    Willing to help others and share workloads
•    Asks others’ opinion
•    Encourages others to get involved
•    Talks about other team members in a positive way
•    Respects the value that different views bring to the team
•    Ability to respond enthusiastically and positively to undergraduate students



•    A-level/HNC standard of education or equivalent in a related subject

•    BSc degree in related area 
•    MSc in relevant field 




The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality. The University is also a member of the Euraxess initiative supporting researchers in Europe.


Requisition ID: 24705