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Research Assistant/Associate

Requisition ID:  2021

Newcastle, GB

Contract Type:  Fixed Term
Posted Date: 


We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.


Salary: £28,331.00 - £30,942.00 

Closing Date 24 June 2020


The role

A postdoctoral position is available within the Laboratory of T cell Regulation at Newcastle University. The Laboratory’s major focus is to understand the role of co-receptors in maintaining immune tolerance (Taylor et al, J.Exp. Med, 2017, Vol. 214(6): 1663-1678; Stathopoulou et al, Immunity, 2018, Vol. 49 (2):247-263). Specifically, the project will address how programmed death-1 receptor (PD-1) regulates T cell populations and translate these findings into immunotherapies for cancer and autoimmune diseases 

You will be involved in discovering new checkpoints in murine and human Tregs that are modulated by PD-1 and other co-receptors such as TIGIT and CD161. You will be expected to possess cellular and biochemical skills, molecular biology skills and have experience in murine work. On identifying key checkpoints, the post holder will develop novel Treg cellular therapeutics involving lentiviral engineering technologies or CRISPR/Cas9 methodologies.

This post is tenable for 3 years. Please contact Dr Shoba Amarnath at shoba.amarnath@newcastle.ac.uk for further information.

As part of our commitment to career development for research staff, the University has developed 3 levels of research role profiles.  These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

Key Accountabilities

•    The project, which is funded by an MRC research grant, will involve understanding the regulatory pathways that maintain the function of murine and human T regulatory cells in health and disease. The individual will be expected to work independently on this research project and determine post-translational pathways that are significantly regulated by co-receptor signalling in Tregs. Specifically, the project will focus of programmed death-1 receptor (PD-1) signalling in Tregs and its associated impact on Treg cell function in health and disease.

•    On identifying key pathways, the post holder will develop new engineered cellular therapeutics using lentiviral or CRISPR/Cas9 technologies.
•    Although working under the general guidance of the principal investigators, they will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial ‘added value’ 
•    Determine appropriate methodologies for research, with advice and support where required 
•    Assess research findings for the need/scope for further investigations 
•    Contribute to the writing up of their research and its dissemination, either through seminar and conference presentations or through publications 
•    Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline 
•    Contribute to grant applications submitted by others and in time develop own research objectives and proposals for funding 
•    May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
•    Start to develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment 
•    Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids 
•    May contribute to events celebrating the public engagement of science/social sciences/humanities 
•    Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.


The Person (Essential)

Knowledge, Skills and Experience 

•    Detailed subject knowledge in the area of research 
•    Experience in cellular immunology techniques such as cell culture, Treg suppression assay, flow cytometry, ELISA assays, Lentiviral engineering, CRISPR/Cas technology, western blotting, CHIP assays
•    High level of analytical and problem solving capability 
•    Ability to communicate complex information with clarity and to encourage the commitment of others 

•    Publications in peer-reviewed journals on Tcell immunology
•    Understanding of statistical programs such as Graph Pad Prism
•    Use of Endnote or other Reference Managers
•    Experience in metabolic assays such as SeaHorse Analysis
•    Experience of research with clear transferable skills and some experience or awareness of the research environment 
•    Presentations at conferences and/or high quality publications 


Attributes and Behaviour

•    Aware of the ethical issues involved in their research work 
•    In a position to bring individual skills and insights to the research 



•    A PhD and experience in the research area required (or close to submission of PhD for Research Assistant level)

Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.


Requisition ID: 2021