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Research Assistant/Associate

Requisition ID:  1406

Newcastle, GB

Contract Type:  Fixed Term
Posted Date: 


We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.


Salary: £28,331 - £30,942 

Closing Date: 21 April 2020

The role


A postdoctoral position is available within Dr.Amarnath’s Laboratory [Laboratory of T cell Regulation] at Newcastle University. The Laboratory’s major focus is understanding role of co-receptors in maintaining immune tolerance. Specifically, the project will address how programmed death-1 receptor (PD-1) activation on T regulatory cells (Tregs) can impact the proteomic landscape in human and mouse Tregs. You will be involved in identifying key pathways in murine and human Tregs that are modulated by PD-1. You will be expected to possess cellular and biochemical skills, molecular biology skills and have experience in T cell biology.


This post is tenable for 18 months. Please contact Dr Shoba Amarnath shoba.amarnath@newcastle.ac.uk for further information.




As part of our commitment to career development for research staff, the University has developed 3 levels of research role profiles.  These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.


Key Accountabilities


  • Although working under the general guidance of Dr Amarnath you will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial ‘added value’
  • The project which is funded by LeoFoundation Future Leader Award will involve understanding the proteomic landscape of murine and human T regulatory Cells in health and disease. You will be expected to work independently on this research project and identify significantly modified protein signature post activation of co-receptor signalling in Tregs. Specifically, the project will focus of programmed death-1 receptor (PD-1) signalling in Tregs and its associated impact on the Treg proteome.
  • Determine appropriate methodologies for research, with advice and support where required
  • Assess research findings for the need/scope for further investigations
  • Contribute to the writing up of their research and its dissemination, either through seminar and conference presentations or through publications
  • Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
  • Contribute to grant applications submitted by others and in time develop own research objectives and proposals for funding
  • May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
  • Start to develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment
  • Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
  • May contribute to events celebrating the public engagement of science/social sciences/humanities
  • Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Translational and Clinical Research Institute


The Person (Essential)

Knowledge, Skills and Experience

  • Experience in cellular immunology techniques such as cell culture, Treg suppression assay, flow cytometry, ELISA assays, 
  • An in-depth understanding of biochemical and molecular biology experience is required such as western blotting and CHIP assays
  • Molecular Biology skills including lentiviral transduction in primary human immune cells.
  • High level of analytical and problem solving capability 
  • Ability to communicate complex information with clarity and to encourage the commitment of others 
  • Experience of research with clear transferable skills and some experience or awareness of the research environment 
  • Presentations at conferences and/or high quality publications 



  • Publications in peer-reviewed journals on Tcell immunology
  • Understanding of statistical programs such as Graph Pad Prism
  • Use of Endnote or other Reference Managers
  • Experience in T cell proteomics
  • Experience in CRISPR/Cas technology


Attributes and Behaviour

  • Aware of the ethical issues involved in their research work
  • In a position to bring individual skills and insights to the research



  • A PhD and experience in the research area required (or close to submission of PhD for Research Assistant level)


The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality.  The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.


Please be advised that due to the minimum salary thresholds imposed by the UKVI, this post may not qualify for University sponsorship under Tier 2 of the points based system.



Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.


Requisition ID: 1406