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Research Assistant/Associate in Proteomics

Requisition ID:  5254

Newcastle, GB

Contract Type:  Fixed Term
Working Pattern:  Full Time
Posted Date: 


We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.


Salary: Research Assistant: £28,331 - £30,046 per annum

            Research Associate £30,942 - £40,322 per annum


Closing Date: 28 October 2020

The Role


Applications are invited for two Research Assistants/Associates to work in the group of Prof Matthias Trost utilising state-of-the-art proteomics to study innate immune responses triggered by bacterial infection of macrophages are regulated by ubiquitylation. Ubiquitylation is an important post-translational modification regulating all biology, including inflammation and cancer. We have recently identified key E3 ligases regulating phagosome functions and the project will characterise the molecular mechanisms of these E3 ligases. The project will exploit the laboratory’s expertise in proteomics, biochemistry and cell biology techniques. Recent papers from our lab include articles in top journals such as EMBO Journal and Nature Microbiology. 


We seek talented and enthusiastic post-doctoral scientists with a background in quantitative mass spectrometry and proteomics. You will have a good academic track record and have published at least one first authored paper in an international journal. You will ideally have experience with ubiquitylation or other post-translational modifications. Knowledge and working experience in cell biological and biochemical techniques would be advantageous, but is not essential. 


The posts are fixed term for 3 years.  Available immediately, but applicants wishing to start at a later time will be considered. 


The positions are based in the Newcastle University Biosciences Institute (NUBI). In the last Research Excellence Framework (REF2014) by the UK government, our institute (then called ICaMB) was 1st for research output amongst all of the UK submitted University biosciences departments and was placed 5th out of 44 UK submissions in the overall scores.


Newcastle upon Tyne is a vibrant city in the northeast of England. In addition to an excellent scientific environment, Newcastle offers an affordable standard of living in an area of outstanding natural beauty with beautiful beaches at the coast and Northumberland countryside.


Further information can be obtained by contacting Prof Matthias Trost (matthias.trost@newcastle.ac.uk) or from the lab’s website: http://trostlab.org

As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles.  These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

Key Accountabilities


  • Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
  • Plan and carry out independent original research encompassing: Investigations leading to the discovery of new knowledge, Analysing data, interpreting and bringing new insights
  • Initiate or participate in inter-disciplinary collaborations as agreed with supervisor
  • Provide guidance, where necessary, to other staff and students including possible supervision of PhD and undergraduate project students as agreed with supervisor
  • Present research findings as posters and oral presentations at conferences
  • Write up research findings for publication and dissemination


The Person 

Knowledge, Skills and Experience 


  • A strong research background in proteomics or quantitative mass spectrometry
  • Experience with maintaining mass spectrometers, ideally Orbitrap type or TIMS-TOF
  • Experience with liquid chromatography
  • Experience with data analysis of proteomics data
  • At least one first-author publication in a recognised peer-reviewed journal (published or submitted)
  • Experience with R for statistical analysis (Desirable)
  • Experience with cell biological and biochemical methods (Desirable)
  • Experience with macrophages or other innate immune cells (Desirable)
  • Experience with cell signalling, especially ubiquitylation (Desirable)
  • Experience of presenting research work at scientific meetings (Desirable)
  • Ability to contribute to writing publications (Desirable)


Attributes and Behaviour


  • Applicants should be ambitious with a demonstrable drive to succeed and produce work at the highest level
  • Ability to work independently 
  • Strong interpersonal skills and ability to work in a team
  • Capacity for original thought  
  • Willingness to take on extra responsibilities, such as the day to day supervision of PhD or undergraduate project students   
  • Willingness to work flexibly by mutual agreement




•    Degree in chemistry, biology, biochemistry, or a related area (Assistant level)
•    Possession of a PhD (Assocaite level)  (or imminent submission of thesis) in chemistry, biology, biochemistry or a related field


Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.


The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality. The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.


Please be advised that due to the minimum salary thresholds imposed by the UKVI, this post may not qualify for University sponsorship under Tier 2 of the points based system.


Requisition ID: 5254