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Research Assistant/Associate: Proteomics characterization of bacterial phagosomes

Requisition ID:  21464

Newcastle, GB

Contract Type:  Fixed Term
Working Pattern:  Full Time
Posted Date:  28-Jul-2022


We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.


What’s in it for you? Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package, plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you. Newcastle is an inclusive global University community where everyone is treated with dignity and respect.  As a University of Sanctuary, we aim to provide a welcoming place of safety for all, offering opportunities to people fleeing violence and persecution.


Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains colleagues from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.



Research Assistant: £29,619 to £31,411 per annum

Research Associate: £32,348 to £42,155 per annum


Closing Date: 28 August 2022


The Role


Applications are invited for a researcher position to work in the group of Prof Matthias Trost to characterise bacterial phagosomes in neutrophils and macrophages by state-of-the-art proteomics techniques. The project is within a team of excellent scientists funded by a Wellcome Investigator Award to study the role of ubiquitylation in phagosome biology. Within this project, we have recently developed exciting methods to isolate highly pure bacterial phagosomes for proteomics analysis. 


We seek a talented and enthusiastic researcher with a background in either microbiology, molecular immunology, biochemistry, cell biology or infection biology. You will have a good academic track record and have published at least one first authored paper in an international journal. You will ideally have experience with flow cytometry, cell biological and biochemical techniques. Knowledge and working experience in mouse handling and infections would be advantageous.


The position is based in the Newcastle University Biosciences Institute (NUBI) an excellent research institute at the Faculty for Medical Sciences of Newcastle University. 


Newcastle upon Tyne is a vibrant city in the northeast of England. In addition to an excellent scientific environment, Newcastle offers an affordable standard of living in an area of outstanding natural beauty with beautiful beaches at the coast and Northumberland countryside.


As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.


The position is available for 3 years with a possibility for further extension. Available immediately, but candidates wishing to start at a later time will be considered.


Further information can be obtained by contacting Prof Matthias Trost (, and from the lab’s website here


Key Accountabilities

  • Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value' 
  • Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements 
  • Determine appropriate methodologies for research, with advice and support where required
  • Contribute to grant applications submitted by others and in time develop own research objectives and proposals for funding 
  • Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
  • Assess research findings for the need/scope for further investigations
  • Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
  • Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
  • May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants 
  • Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute
  • May contribute to events celebrating the public engagement of science/social sciences/humanities
  • Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment
  • Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
  • Plan and carry out independent original research, encompassing investigations leading to the discovery of new knowledge and Analysing data, interpreting and bringing new insights
  • Initiate or participate in inter-disciplinary collaborations as agreed with supervisor
  • Provide guidance, where necessary, to other staff and students including possible supervision of PhD and undergraduate project students as agreed with supervisor
  • Present research findings as posters and oral presentations at conferences
  • Write up research findings for publication and dissemination


The Person


Knowledge, Skills and Experience

  • A strong research background in microbiology, biochemistry or molecular immunology
  • Strong experience in flow cytometry
  • Experience with infection biology
  • At least one first-author publication in a recognised peer-reviewed journal (published or submitted)
  • Experience of presenting research work at scientific meetings 
  • Ability to contribute to writing publications 


  • Experience with mouse infections
  • Experience with proteomics analysis or willingness to learn 
  • Experience of cell biological methods such as microscopy 
  • Experience with macrophages or other innate immune cells 


Attributes and Behaviour

  • You should be ambitious with a demonstrable drive to succeed and produce work at the highest level
  • Ability to work independently    
  • Strong interpersonal skills and ability to work in a team
  • Capacity for original thought
  • Willingness to take on extra responsibilities, such as the day-to-day supervision of PhD and undergraduate project students



  • Degree in biology, biochemistry, immunology, chemistry or a related area
  • Possession of a PhD (or imminent submission of thesis) in biology, immunology, biochemistry, chemistry or a related field. Candidates close to submission of PhD will be appointed at Research Assistant level initially


The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality. The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.


Requisition ID: 21464