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Research Assistant / Research Associate

Requisition ID:  20741

Newcastle, GB

Contract Type:  Fixed Term
Working Pattern:  Full Time
Posted Date:  21-Jun-2022


We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

What’s in it for you? Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.


Newcastle is an inclusive global University community where everyone is treated with dignity and respect.  As a University of Sanctuary, we aim to provide a welcoming place of safety for all, offering opportunities to people fleeing violence and persecution.


Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains colleagues from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.



Research Assistant: £28,756 to £30,497 per annum

Research Associate: £31,406 to £32,344 per annum


Closing Date: 13 July 2022


The Role


We are seeking an experienced and dedicated researcher to join the Newcastle Fibrosis Research Group (NFRG), whose purpose is to understand the biological processes that lead to the progression of age-related chronic diseases to loss of organ function and/or cancer. By developing a deeper understanding of processes such as inflammation, cellular senescence, fibrosis and tumour development we aim to unlock new drug targets and biomarkers that provide solutions to diseases that are highly prevalent in populations. 


This project is to determine how adaptive changes in the diseased liver drive the development of fibrosis, and we are interested in epigenetic changes that occur in response to epithelial damage in the liver and in particular as caused by fat accumulation in hepatocytes as typical of non-alcoholic fatty liver disease (NAFLD). 


You will focus on defining epigenetic drivers of fibrosis such as miRNAs and histone modifying enzymes using a bespoke and unique human liver tissue model that brings significant competitive advantage to the project. Your role will be to exploit our human model of liver disease to define epigenetic drug targets and then manipulate these molecules with inhibitors or other molecular approaches (e.g. siRNA). 


This is a full time position, fixed term until 1 January 2024


For informal enquiries, please contact Prof Derek Mann

Key Accountabilities

  • Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value' 
  • Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements 
  • Determine appropriate methodologies for research, with advice and support where required
  • Contribute to grant applications submitted by others and in time develop own research objectives and proposals for funding 
  • Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
  • Assess research findings for the need/scope for further investigations
  • Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
  • Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
  • May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants 
  • Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.
  • May contribute to events celebrating the public engagement of science/social sciences/humanities
  • Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment


The Person


Knowledge, Skills and Experience

  • Ability to work well as part of a team and rapidly acquire new skills
  • Detailed subject knowledge (PI to describe subject knowledge required) in the area of research 
  • Likelihood of advanced skills directly related to the research projects 
  • High level of analytical and problem-solving capability 
  • Ability to communicate complex information with clarity and to encourage the commitment of others 
  • Experience of research with clear transferable skills and some experience or awareness of the research environment 
  • Presentations at conferences and/or high-quality publications 


  • Cell culture experience
  • Molecular biology skills  
  • Evidence of publication 
  • Analytical skills including data analysis and presentation


Attributes and Behaviour

  • Hard working
  • Comfortable working independently as well as in a team research environment
  • A passion for research
  • Flexible working


  • Strong publication record and desire to progress to fellowship applications
  • Supervisory experience, in particular with UG and/or PG research projects



  • A PhD (Essential for Associate) or nearing completion (Assistant) and experience in the research area required

The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality. The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.


Requisition ID: 20741