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Clinical Research Associate

Requisition ID:  8162
Location: 

Newcastle, GB

Contract Type:  Fixed Term
Working Pattern:  Full Time
Posted Date:  11-Jul-2021

 

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

 

Salary: £31,003.00 - £51,069.00 per annum

Closing Date: 31 July 2021

The role


Autologous Tolerogenic Dendritic cells for Rheumatoid Arthritis (AuToDeCRA) is the Musculoskeletal Research Groups flagship programme, investigating the potential of a cellular therapy, derived from a rheumatoid arthritis patient’s own peripheral blood, to intercept the disease process and we are now preparing for our second human trial of this therapy, AuToDeCRA-2.  This study will compare different routes of administration, using immune monitoring to track the impact of this novel cellular therapy over a period of three months.  It may also be possible to track the injected cells using MRI. 

 

This post provides a unique opportunity for an ambitious clinician to develop a practical understanding of experimental medicine research.  You will be responsible for delivering AuToDeCRA-2. Playing a central role in the team, acting as a liaison between the research laboratory team, the Good Manufacturing Practice (GMP) advanced therapies laboratory, the NHS rheumatology team and the NIHR Clinical Research Facility.   You will identify potential participants, via face-to-face and telephone consultations, explaining the study and obtaining consent. You will be responsible for overall trial management and logistics, including oversight of study visits, preparing study reports and manuscripts. 

 

We are looking for a dynamic, conscientious, self-motivated team player, with a thirst for new knowledge and an appetite for discovery.  You will hold a medical degree and a license to practice in the UK.  

 

This post is fixed term for two years.   

 

Informal enquiries can be made to John.isaacs@ncl.ac.uk or Arthur.pratt@ncl.ac.uk 

 

You should attach a statement to their application that describes their research interests and, in particular, highlights their relevant experience.


Key Accountabilities 


•    Contribution to the research programme of the Translational and Clinical Research Institute under the clear guidance of a member of an academic staff or Principal Investigator.
•    Develop a logistical framework for participants, to enable efficient participation – in particular arranging for imaging investigations if relevant, and liaison between the advanced therapies facility, musculoskeletal research laboratories, and clinical research facility and trial team.
•    Learn to perform intradermal injections.
•    Develop a standard operating procedure for handling of research blood samples after acquisition.
•    Identify suitable participants for AuToDeCRA-2 and, where appropriate, obtain informed consent.
•    Oversee study participation, including cell injection.
•    Ensure that, once collected, research samples are processed and stored appropriately, according to the standard operating procedure.
•    Alongside other AuToDeCRA-2 investigators, devise an appropriate data analysis plan for the study.
•    Be prepared to contribute to events celebrating the public engagement of science/social sciences/humanities.
•    Co-ordinate own work with that of others, deal with problems which may affect the achievement of research objectives and contribute to the planning of the project
•    Present information on research progress and outcomes to the Principal Investigator or groups overseeing the research project and at national and international meetings.
•    Write up results from own research activity and provide input into the research project’s dissemination, in whatever form (report, papers, chapters)
•    Work to deadlines and manage, with support, competing priorities
•    Ensure that personal knowledge and training in relevant fields of study is kept up to date
•    May work with other researchers in a team and actively participate in collaborative research, liaising with research colleagues and support staff on day-to-day issues.
•    May provide guidance as required to any support staff and/or research students
•    May in some parts of the University work alongside, and help informally, students working in the same laboratory
•    May be involved in the recruitment and delivery of other related clinical trials and support the specialist clinical rheumatology services.


The Person 


Knowledge, Skills and Experience 

Essential
•    Considerable subject knowledge in rheumatology and autoimmune rheumatic disease 
•    Ability to work flexibly according to study needs 
•    Ability to work collaboratively with colleagues 
•    Good level of analytical skills and the ability to communicate complex information clearly, both orally and through the written word. 
•    Ability to use personal initiative and creativity to solve research problems 
•    Ability to extract and interpret complex medical information from medical records 
•    Interpersonal skills to communicate effectively with patients and families 
•    Excellent planning and organisation skills and ability to prioritise competing demands 
•    Excellent record keeping 


Desirable 
•    Demonstrable clinical research experience in rheumatology and autoimmune rheumatic disease, particularly rheumatoid arthritis
•    Training in GCP and taking informed consent
•    Evidence of academic aptitude (e.g. publications/presentations) 
•    Experience of using electronic patient records
•    Experience in the recruitment, conduct and care of patients participating in experimental medicine studies 


Attributes and Behaviour 
•    Able to work as part of a team but also independently 
•    Able to collect, organise and analyse complex datasets 
•    Conscientious
•    Enthusiastic and curious 
•    Ability to work flexibly, and under pressure 
•    Good interpersonal skills; able to effectively work with others, including colleagues, other staff, patients and their families

 

Qualifications 
•    Degree in medicine 
•    GMC registration 
•    MRCP part 1 UK or equivalent

 

 

Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.

 

The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality. The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.

 

Requisition ID: 8162