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Bioinformatician

Requisition ID:  5447
Location: 

Newcastle, GB

Contract Type:  Fixed Term
Working Pattern:  Full Time
Posted Date:  19-Nov-2020

 

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

 

Salary: £30,942 - £40,322 per annum

 

Closing Date: 3 January 2021

The Role

 

We are looking for an ambitious, industrious and dynamic Bioinformatician to develop cutting edge techniques and applications to interrogate and identify genetic causes, risks and biomarkers in the extensive, ethnically diverse, genetic and phenotypic data collected through the MRC International Centre for Genomic Medicine in Neuromuscular Disease (ICGNMD) project.

 

You will be able to demonstrate evidence of independent working within a research environment and preferably have a strong background in biological sciences including genetics. You will work with Principal Investigators and research groups in the Wellcome Centre for Mitochondrial Research and the John Walton Muscular Dystrophy Research Centre that together comprise the Newcastle component of the ICGNMD. You will also work in close collaboration with the lead informatician, Jana Vandrovcova, based at UCL, London.  You will provide bioinformatic support for genomic, epigenetic, proteomic and transcriptomic integrative analyses, establishing bioinformatics pipelines and maintaining biological databases. You should have a proven track record (evidenced by publications and/or experience in a previous role) and show an enthusiasm and intellectual curiosity to apply a broad range bioinformatics tools to understanding the genetics of mitochondrial and neuromuscular diseases.

 

The post is available on a full time, fixed term basis for 2 year with potential for further renewal.

 

For informal enquiries regarding the role, please contact Professor Bobby McFarland: Robert.McFarland@ncl.ac.uk 

 

Information about the Faculty of Medical Sciences is available at: https://www.ncl.ac.uk/medicalsciences/

 

Key Accountabilities

 

  • To develop cutting edge techniques and applications to interrogate and identify genetic causes, risks and biomarkers in extensive, ethnically diverse, genetic and phenotypic data
  • To provide bioinformatic support for genomic, epigenetic, proteomic and transcriptomic integrative analyses, establishing bioinformatics pipelines and maintaining biological databases
  • To apply a broad range of bioinformatics tools to understanding the genetics of mitochondrial and neuromuscular diseases
  • Responsible for instructing less experienced student and staff members on various techniques and the design of experimental protocols
  • Supporting the PhD/MSc supervision within the department for students undertaking genomics projects training them as per other users
  • Writing scientific papers

 

The Person

Knowledge, Skills and Experience

 

  • Experience working with in a high-performance-computing environment (e.g. PBS/Torque, LSF, or Slurm)
  • Experience programming in  Linux/Unix, Python, R or Perl.
  • Experience analysing, visualising and annotating high-throughput datasets, particularly genomic, but also including transcriptomic orproteomic data
  • An understanding and interest in evaluation and possible acquisition of the latest breakthrough technologies in bioinformatics and computational biology
  • Grounded theoretical knowledge of genetic, cell and molecular biology
  • Experience of working with large sets of genetic data in a research setting
  • Relevant IT experience
  • Experience in dealing with large, publically available, datasets (e.g. from Genomics England, 1000 Genomes or the EGA) (Desirable)
  • Direct experience of single cell transcriptomic, epigenetic, proteomic or genomic datasets (Desirable)
  • Direct experience of high dimensional flow cytometry data set analysis (Desirable)
  • Proficiency in  statistical analytical packages such as R or SAS. Knowledge of SQL databases, web development (Desirable)
  • Experience in use of REDCap (Desirable)
  • Knowledge of LIMS design and implementation (Desirable)
  • Evidence of contributing to successful applications for national/international peer reviewed research funding (Desirable)
  • Evidence of completed research and publications in peer reviewed journals (Desirable)
  • Experience in the design and analysis and delivery of research projects (Desirable)

 

Attributes and Behaviour

 

  • Excellent interpersonal and communication skills (both written and oral) to be able to work alongside individuals with different levels of technical knowledge
  • Maintain a contemporary knowledge of developments in bioinformatics
  • Exhibit a high level of motivation and initiative
  • Excellent organisational skills
  • Team approach to working
  • Creative problem solving
  • Strong attention to detail
  • Ability to work flexibly
  • Ability and willingness to travel locally, within UK and internationally for meetings and conferences
  • Knowledge and understanding of the regulatory framework and good research practice underpinning research (Desirable)
  • Understanding of health and safety regulations and procedures within a higher education environment (Desirable)
  • Outline understanding of UK research funding procedures (Desirable)

 

Qualifications

 

  • Relevant postgraduate degree e.g. PhD. in bioinformatics or equivalent qualifications and/or experience in a relevant scientific/technical role

 

Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.

 

 

The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality.  The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.

 

Please be advised that due to the minimum salary thresholds imposed by the UKVI, this post may not qualify for University sponsorship under Tier 2 of the points based system.

 

Requisition ID: 5447