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Research Technician

Requisition ID:  1399

Newcastle, GB

Contract Type:  Fixed Term
Posted Date: 


We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.


Salary: £21,814.00 - £23,067.00 

Closing Date: 30 January 2020

The role


This is an exciting post funded by Orthopaedic Research UK. At the North of England Bone and Soft Tissue Tumour Service based in Newcastle, patients suffering from sarcomas receive treatment including surgery. Sarcomas are rare bone and soft tissue cancers. The goal of surgery is to remove the sarcoma along with a covering of normal tissue in order to ensure good clearance. Surgeons are always balancing the removing of enough normal tissue so that the cancer outcome is not compromised with the fact that the more tissue that is removed, the more it impacts on functional outcome. This project involves the preclinical validation of sarcoma cell surface markers as tools for the pre and intra-operative enhancement of imaging to help guide the surgery.  This is a unique opportunity for you to learn about sarcoma biology, gain skills in radiochemistry and experience of working with mouse models.


You will carry out maintenance of sarcoma cell lines, assessment of expression of candidate cell surface imaging targets and preparation of cells for implantation into mice. You will also perform in vitro cell binding assays to assess the performance of the monoclonal antibodies following conjugation with infrared dyes and radiotracers. You will  set up the xenografts for the in vivo phase of the project.


You will have a minimum BTEC HNC/HND in relevant subject or equivalent experience. You will be enthusiastic and hard working as well as adaptable and willing to learn new techniques.  You will have experience in cell culture. Experience of working with animal models, handling clinical samples and in flow cytometry (including cell sorting) are desirable but are not essential. Experience in molecular biology and antibody based analytical techniques is also desirable but not essential.


You will work closely with Kenneth Rankin (Consultant Sarcoma Surgeon), James Knight (Lecturer in Radiochemistry) and Helen Blair (Senior Research Associate with expertise in mouse models). You will work across sites at both the Paul O’Gorman Building and at the School of Natural and Environmental Sciences.


Additional information about the project is available here: https://www.ncl.ac.uk/medicalsciences/research/groups/sarcoma/


This is a fixed term post until 31 January 2021.


For informal queries please contact Kenneth Rankin on k.s.rankin@ncl.ac.uk




























Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.


Requisition ID: 1399