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Research Assistant/Associate

Requisition ID:  1074

Newcastle, GB

Contract Type:  Fixed Term
Posted Date:  31-Oct-2019

We are a world class research-intensive university. We deliver teaching and learning of the highest quality. We play a leading role in economic, social and cultural development of the North East of England. Attracting and retaining high-calibre people is fundamental to our continued success.

Salary: £28,331 - £44,045 

Closing Date: 30 November 2019


An exciting opportunity is available to join a multicentre team led by Prof Olaf Heidenreich, Prof Constanze Bonifer, Prof Peter Cockerill and Dr Helen Blair to identify new and more effective treatments for acute myeloid leukaemia (AML)


Building on the identification of regulatory networks required for propagation of FLT3-ITD AML (Assi et al, Nat. Genet. 2019), a type of leukaemia with poor prognosis and propensity for the development of drug resistance, you will develop strategies for therapeutic intervention.


Based at the Wolfson Childhood Cancer Research Centre at Newcastle University and working closely with researchers at the University of Birmingham, you will employ established patient derived xenografts to validate targets, test novel therapies and understand the mechanism of relapse disease.


You will hold a PhD (or be near completion of a PhD for appointment at Research assistant) in cancer research or related subject. You will have experience of cell culture and molecular biology techniques.


You will have good communication and team working skills and contribute to direction of the project.


This post is tenable until 28 February 2023.


Informal enquiries can be made to Dr Helen Blair ( or Prof. Olaf Heidenreich (


As part of our commitment to career development for research staff, the University has developed 3 levels of research role profiles.  These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.


Key Accountabilities


  • Culture of leukaemia cell lines and primary derived patient samples.
  • Extraction of high-quality RNA, DNA and protein.
  • Flow cytometry.
  • Gene expression and RNAi, CRISPR/Cas9 gene editing in vitro and in vivo.
  • Xenotransplantation of human AML cells in mice, assessing health and monitoring engraftment.
  • Drug pharmacology and in vivo dose finding studies.
  • in vivo imaging.
  • in vivo therapeutic efficacy testing.
  • Maintaining current knowledge of research area and latest technologies.
  • Independent planning and communication of experimental strategies.
  • Independent analysis and interpretation of experimental data.
  • Perform statistical and data analyses to produce robust and reproducible data.
  • Presentation of results at meetings and assistance with writing publications.
  • Assistance in the supervision of undergraduate and postgraduate students in the laboratory.
  • Active participation with significant contributions to laboratory meetings e.g. problem solving, internal seminars, journal clubs.
  • The performance of risk assessments and maintaining safety laboratory records (e.g. COSHH) in consultation with academic staff.
  • Organisation   and   assistance   in   general   laboratory   duties.


The Person (Essential)


Knowledge, Skills and Experience


  • Experience of a range of molecular biology techniques.
  • Experience of cell culture.
  • Experience of CRISPR/Cas9 and gene knock-down technologies.
  • Experience of flow cytometery.
  • Completion of PILAB training and Home Officer PIL holder.
  • Experience of animal handling and regulated procedures.
  • Excellent oral communication and writing skills.
  • Excellent information technology and computing skills.
  • Experience of presenting work at scientific meetings


Attributes and Behaviour


  • Capacity for original thought.
  • Enthusiastic and hard working.
  • Reliable and honest.
  • Organised and good attention to detail.
  • Good team working skills.
  • Ability to contribute to the direction of the project.
  • Be able to work independently.
  • Have an interest in animal welfare.




  • Bachelor’s degree (or equivalent) in a relevant science subject.
  • PhD in cancer research or related subject (or near completion for appointment at Research Assistant level).


Newcastle University is committed to being a fully inclusive Global University which actively recruits, supports and retains staff from all sectors of society.  We value diversity as well as celebrate, support and thrive on the contributions of all our employees and the communities they represent.  We are proud to be an equal opportunities employer and encourage applications from everybody, regardless of race, sex, ethnicity, religion, nationality, sexual orientation, age, disability, gender identity, marital status/civil partnership, pregnancy and maternity, as well as being open to flexible working practices.

Requisition ID: 1074


The University holds a silver Athena SWAN award in recognition of our good employment practices for the advancement of gender equality.  The University also holds the HR Excellence in Research award for our work to support the career development of our researchers, and is a member of the Euraxess initiative supporting researchers in Europe.


Please be advised that due to the minimum salary thresholds imposed by the UKVI, this post may not qualify for University sponsorship under Tier 2 of the points based system.